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Information and Links
for Stem Cell Treatments, ALS and more
Interest in Nepsis? Nepsis Institute Patient Enrollment Form
"Aren't embryonic stem cells better than adult or iPS?" (web page)
Stem Cell Medicine Jumps to Warp Speed (.pdf format)(allow time to open)
Nepsis Institute Stem Cell Slide Show (power point)
ALS Ependyma Hypothesis (web page)
Stem Cell Pioneers (web page)
M.S. Site by Jim Haverlock (flyin-blind web page)
Scientific summary of issues & hypotheses regarding ALS (especially sporadic or nonfamilial).
Science Daily - This line of animal research supports Dr. A.G. Payne's 2004 hypothesis – which predates this lab study -- that the best near-term approach to extending life and improve its quality for ALS patients is to “rip out the bad wiring and replace it with good” (via stem cell therapy). A whole systems approach. However, Dr. Payne believes that the "bad wiring" includes not just motor neurons and astrocytes, but also the ependymal cells that line the ventricles in the ALS sufferer's brain and which churns out CSF (Cerebral Spinal Fluid) which damages these vital CNS components
Experimental regimen targeting the ependyma slows disease progression in four patients with amyotrophic lateral sclerosis.
High dose L-Theanine might prove of merit in helping put a dent in the glutamate excitotoxicity that characterizes nonfamilial ALS: J Herb Pharmacother. 2006;6(2):21-30.
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. Nathan PJ, Lu K, Gray M, Oliver C.
Behavioural Neuroscience Laboratory, Department of Physiology, Monash Center for Brain and Behaviour, Monash University, Australia. Nathan@med.monash.edu.au
L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.
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